Peer-reviewed research advancing the understanding of drug sequestration, adsorption phenomena and molecule–membrane interactions in critical care and extracorporeal therapies.
Peer-reviewed publications
Journals represented
Years of research
international collaborations
These innovations provide the scientific foundation for broad rangee of applications designed to anticipate, assess, and solve complex molecule-materiel interaction challenges.
Understanding the impact of polyacrylonitrile-derived filters on antifungal drug exposure during CRRT.
Investigating the elimination and sequestration of aminoglycosides, vancomycin, cefepime and cefotaxime in extracorporeal circuits.
Advancing predictive approaches to characterize interactions between therapeutic molecules and filtration materials.
Optimizing drug administration strategies during continuous renal replacement therapy and extracorporeal support.
Integrated solutions to understand, predict, and remove harmful interactions for better health and a cleaner environment.
Letter to the Editor regarding “Impact of Continuous Renal Replacement
Therapy with Polyacrylonitrile-Derived Filter on Caspofungin Concentration: A
Retrospective Study
Julien Massol, Valentin Maulet, Lionel Lamhaut, Frédéric J Baud
January 2026, Infectious Diseases and Therapy 15(3)
https://doi.org/10.1007/s40121-025-01289-x
In vitro assessment of cefepime adsorption in filters used during renal
replacement therapy
Valentin Maulet, Jessica Le Ven, Louis Fonlupt, Céline Mory, Solange Corriol- Rohou, Frédéric J Baud and Alban Le Monnier
The International Journal of Artificial Organs, 1–7, 2025,
https://doi.org/10.1177/03913988251356124
Is Caspofungin Efficient to Treat Invasive Candidiasis Requiring Continuous
Veno-Venous Hemofiltration? A Case Report.
Raphalen, J. H., A. Marcais, P. Parize, B. Pilmis, A. Lillo-Lelouet, L. Lamhaut, and F. J. Baud
Therapie 76 (5): 512–15
https://doi.org/10.1016/j.therap.2020.12.013
Elimination of Cefotaxime Using Polysulfone and Polyacrylonitrile-Derived
Filters: An in Vitro Assessment.
Le Ven, Jessica, Camille Pellan, Valentin Maulet, Alban Le Monnier, and Frédéric J. Baud
The International Journal of Artificial Organs 46 (2): 113–19
https://doi.org/10.1177/03913988221143803
Is Preloading with Amikacin a Measure Able to Mitigate Sequestration? A
Preliminary in Vitro Study
Houzé, Pascal, Jean-Herlé Raphalen, Valentin Maulet, Lionel Lamhaut, and Frédéric J. Baud.
The International Journal of Artificial Organs, January, 3913988241310043
https://doi.org/10.1177/03913988241310043
Continuous Renal Replacement Therapy in the Treatment of Severe
Hyperkalemia: An in Vitro Study.
Houzé, Pascal, Frédéric Joseph Baud, Jean-Herlé Raphalen, Anaïs Winchenne, Sonia Moreira, Philippe Gault, Pierre Carli, and Lionel Lamhaut
The International Journal of Artificial Organs 43 (2): 87–93
https://doi.org/10.1177/0391398819865748
Are We Correctly Treating Invasive Candidiasis under Continuous Renal
Replacement Therapy with Echinocandins? Preliminary in Vitro Assessment
Baud, Frederic J., Vincent Jullien, Philippe-Henri Secrétan, Pascal Houzé, and Lionel Lamhaut
Anaesthesia Critical Care & Pain Medicine 40 (1): 100640
https://doi.org/10.1016/j.accpm.2020.01.007
Caspofungin Sequestration in a Polyacrylonitrile-Derived Filter. Increasing the
Dose Does Not Mitigate Sequestration.
Baud, Frédéric J., Vincent Jullien, Marie Desnos-Ollivier, Lionel Lamhaut, and Olivier Lortholary
International Journal of Antimicrobial Agents, October, 107007
https://doi.org/10.1016/j.ijantimicag.2023.107007
Vancomycin Sequestration in ST Filters: An In Vitro Study.
Baud, Frédéric J., Pascal Houzé, Jean-Herlé Raphalen, Pascal Philippe, and Lionel Lamhaut
Antibiotics (Basel, Switzerland) 12 (3): 620
https://doi.org/10.3390/antibiotics12030620
Alteration of the Pharmacokinetics of Aminoglycosides by Adsorption in a
Filter during Continuous Renal Replacement Therapy. An in Vitro Assessment.
Baud, Frédéric J., Pascal Houzé, Pierre Carli, and Lionel Lamhaut
Therapie 76 (5): 415–24
https://doi.org/10.1016/j.therap.2020.10.005
Disposition of Gentamicin and Amikacin in Extracorporeal Membrane
Oxygenation Using a Heparin-Coated Filter: An in Vitro Assessment.
Baud, F.J., T. Jetha-Jamal, S. Vicca, J-H. Raphalen, and L. Lamhaut.
International Journal of Arfificial Organs 1:1–5
https://doi.org/10.1177/03913988221097432
Elimination of Voriconazole during Continuous Renal Replacement Therapy.
An in Vitro Assessment.
Baud, F.J.
In Metabolism. Rein, edited by SFAR.
Paris: Arnette.
Elimination of Three Doses of Gentamicin over Three Consecutive Days Using
a Polyacrylonitrile-Derived Filter: An in Vitro Assessment.
Baud, F. J., V. Seif, P. Houze, J. H. Raphalen, B. Pilmis, P. Carli, and L. Lamhaut
Int J Artif Organs 44 (10): 641–50
https://doi.org/10.1177/03913988211032236
Elimination of Fluconazole during Continuous Renal Replacement Therapy.
An in Vitro Assessment.
Baud, F. J., V. Jullien, T. Abarou, B. Pilmis, J. H. Raphalen, P. Houze, P. Carli, and L. Lamhaut
Int J Artif Organs 44 (7): 453–64
https://doi.org/10.1177/0391398820976144
Diafiltration Flowrate Is a Determinant of the Extent of Adsorption of
Amikacin in Renal Replacement Therapy Using the ST150((R))-AN69 Filter: An
in Vitro Study.
Baud, F. J., P. Houze, J. H. Raphalen, A. Winchenne, P. Philippe, P. Carli, and L. Lamhaut
Int J Artif Organs 43 (12): 758–66
https://doi.org/10.1177/0391398820911928
Does Pharmacokinetics in the Central Compartment Evidence Routes of
Elimination During Continuous Renal Replacement Therapy in Ex Vivo
Model?
Baud, F. J., P. Houze, J. H. Raphalen, and L. Lamhaut
Crit Care Med 48 (2): e163–64
https://doi.org/10.1097/CCM.0000000000004036
Should In Vitro and In Vivo Studies on Antimicrobial Agents during
Continuous Renal Replacement Therapy Comply with General Principles of
Pharmacokinetics?
Baud, F. J., and P. Houze
Antimicrob Agents Chemother 64 (6)
https://doi.org/10.1128/AAC.00388-20