Based on Neckepur expertise and scientific publications led by Prof. F. BAUD, EMA & ANSM avoid use of polyacrylonitrile membranes during continuous renal replacement therapy for patients treated with caspofungin.

Direct healthcare professional communication (DHPC): Caspofungin: recommand avoid use of polyacrylonitrile membranes during continuous renal replacement therapy. 10.09.25

Read official communication

• Houzé, Pascal, Jean-Herlé Raphalen, Valentin Maulet, Lionel Lamhaut, and Frédéric J. Baud.
• “Is Preloading with Amikacin a Measure Able to Mitigate Sequestration? A Preliminary
  in Vitro Study.” The International Journal of Artificial Organs, January, 3913988241310043.

• Baud, Frédéric J., Pascal Houzé, Jean-Herlé Raphalen, Pascal Philippe, and Lionel Lamhaut.
• “Vancomycin Sequestration in ST Filters: An In Vitro Study.” Antibiotics (Basel, Switzerland) 12 (3): 620.

• Baud, Frédéric J., Vincent Jullien, Marie Desnos-Ollivier, Lionel Lamhaut, and Olivier
  Lortholary.
• “Caspofungin Sequestration in a Polyacrylonitrile-Derived Filter. Increasing the Dose Does Not Mitigate Sequestration.” International Journal of Antimicrobial Agents, October, 107007.

• Le Ven, Jessica, Camille Pellan, Valentin Maulet, Alban Le Monnier, and Frédéric J. Baud.
• “Elimination of Cefotaxime Using Polysulfone and Polyacrylonitrile-Derived Filters: An in Vitro Assessment.” The International Journal of Artificial Organs 46 (2): 113–19.

• Baud, F.J., T. Jetha-Jamal, S. Vicca, J-H. Raphalen, and L. Lamhaut.
• “Disposition of Gentamicin and Amikacin in Extracorporeal Membrane Oxygenation Using a Heparin-Coated Filter: An in Vitro Assessment.” International Journal of Arfificial Organs 1:1–5

• Baud, F. J., V. Jullien, T. Abarou, B. Pilmis, J. H. Raphalen, P. Houze, P. Carli, and L.
  Lamhaut.
• “Elimination of Fluconazole during Continuous Renal Replacement Therapy. An in Vitro Assessment.” Int J Artif Organs 44 (7): 453–64.

• Baud, F. J., V. Seif, P. Houze, J. H. Raphalen, B. Pilmis, P. Carli, and L. Lamhaut.
• “Elimination of Three Doses of Gentamicin over Three Consecutive Days Using a Polyacrylonitrile-Derived Filter: An in Vitro Assessment.” Int J Artif Organs 44 (10):641–50.

• Baud, F.J.
• “Elimination of Voriconazole during Continuous Renal Replacement Therapy. An in Vitro Assessment.” In Metabolism. Rein, edited by SFAR. Elimination of Voriconazole during Continuous Renal Replacement Therapy. An in Vitro Assessment.
  Paris: Arnette.

• Baud, Frédéric J., Pascal Houzé, Pierre Carli, and Lionel Lamhaut.
• “Alteration of the Pharmacokinetics of Aminoglycosides by Adsorption in a Filter during Continuous Renal Replacement Therapy. An in Vitro Assessment.” Therapie 76 (5): 415–24.

• Baud, Frederic J., Vincent Jullien, Philippe-Henri Secrétan, Pascal Houzé, and Lionel Lamhaut.
• “Are We Correctly Treating Invasive Candidiasis under Continuous Renal Replacement Therapy with Echinocandins? Preliminary in Vitro Assessment.” Anaesthesia Critical Care & Pain Medicine 40 (1): 100640.

• Raphalen, J. H., A. Marcais, P. Parize, B. Pilmis, A. Lillo-Lelouet, L. Lamhaut, and F. J. Baud.
• “Is Caspofungin Efficient to Treat Invasive Candidiasis Requiring Continuous Veno-Venous Hemofiltration? A Case Report.” Therapie 76 (5): 512–15.

• Baud, F. J., and P. Houze.
• “Should In Vitro and In Vivo Studies on Antimicrobial Agents during Continuous Renal Replacement Therapy Comply with General Principles of Pharmacokinetics?” Antimicrob Agents Chemother 64 (6).

• Baud, F. J., P. Houze, J. H. Raphalen, A. Winchenne, P. Philippe, P. Carli, and L. Lamhaut.
• “Diafiltration Flowrate Is a Determinant of the Extent of Adsorption of Amikacin in Renal Replacement Therapy Using the ST150((R))-AN69 Filter: An in Vitro Study.” Int JArtif Organs 43 (12): 758–66

• Houzé, Pascal, Frédéric Joseph Baud, Jean-Herlé Raphalen, Anaïs Winchenne, Sonia Moreira, Philippe Gault, Pierre Carli, and Lionel Lamhaut.
• “Continuous Renal Replacement Therapy in the Treatment of Severe Hyperkalemia: An in Vitro Study.” The International Journal of Artificial Organs 43 (2): 87–93.

• Baud, F. J., P. Houze, J. H. Raphalen, and L. Lamhaut.
• “Does Pharmacokinetics in the Central Compartment Evidence Routes of Elimination During Continuous Renal Replacement Therapy in Ex Vivo Model?” Crit Care Med